MiBrainTM is a breakthrough solution for fuelling the brain and supporting cognitive performance. MiBrainTM is safe and ideally suited for use in nutritional products. Providing adequate nutrition through fortification is one of the greatest success stories in the history of public health.

MiBrainTM is developed ready for use in food products through regulatory approval and through co-operation of scientists in several countries with decades of experience in the field. The scientific development and its planned consumption on a regular basis has been compared to discovery of the beneficial properties of water fluoridation in tooth decay reduction.

 

Although MiBrainTM represents a completely unique, patented and novel combination of the above bioactive ingredients there is a long history of human exposure to its key components.

 

Choline

Humans can produce small amounts of choline, however, most individuals must consume this nutrient through the diet to supplement the endogenously produced amount to prevent deficiency. In the body choline is a component of the key brain neurotransmitter acetylcholine as well as other brain and nervous tissues. Choline is also a dietary element that is vital for the structural integrity of cell membranes, transmembrane signalling, lipid and cholesterol transport, methyl metabolism. Choline availability modulates brain development in the foetus and infant, and in the adult is important for normal liver and muscle function (1). Loss of cholinergic neurones is associated with impaired cognitive function, memory loss and Alzheimer’s disease (2).

In the EU there are three authorised health claims for choline.

Succinate

Succinate is formed endogenously as a component of the Tricarboxylic acid cycle (TCA), the final common oxidative pathway for carbohydrates, fats and amino acids. The Scientific Committee on Foods (SCF) concluded for succinic acid in 1990.

“The anion occurs in nature and plays a role as an intermediate metabolite in the citric acid cycle”.

 

Succinic acid is therefore present in almost all plant and animal tissues. Succinic acid is approved for use in foods as a flavour enhancer and pH control agent (1).

In the US, succinic acid is permitted for addition to food as an ingredient Generally Recognised as Safe (GRAS) (2).
Succinate is substrate for the cellular energy making machinery in mitochondria as well as a signalling molecule reflecting the cellular metabolic state (3).

Nicotinamide

Nicotinamide (NAM) is a soluble organic compound belonging to the group of B vitamins. Along with nicotinic acid, nicotinamide is often referred to by the generic name niacin which is found in a wide range of foods. In the EU there are six authorised health claims for niacin:

Niacin contributes to normal psychological function (1).

Niacin contributes to normal energy-yielding metabolism (1).

Niacin contributes to normal functioning of the nervous system (1)

Niacin contributes to the maintenance of normal mucous membranes (1).

Niacin contributes to the maintenance of normal skin (1).

Niacin contributes to the reduction of tiredness and fatigue (1).

Modern anti-aging research is aimed at defining the key pathways to sustain high NAD+ turnover. The notion of using NAD+ precursors to boost NAD+ is now beginning to be translated into human studies, NAD+ precursors, such as Niacin, are being safe and naturally available and having potential to improve human health and longevity.